Scintigraphic evaluation of the pharmacokinetics of a soluble polymeric drug carrier
Identifieur interne : 000307 ( Main/Exploration ); précédent : 000306; suivant : 000308Scintigraphic evaluation of the pharmacokinetics of a soluble polymeric drug carrier
Auteurs : RBID : ISTEX:259_1992_Article_BF00177374.pdfEnglish descriptors
- KwdEn :
Abstract
There is a growing interest in the use of macromolecular carriers for therapeutic agents. If these carriers can be labelled with an appropriate gamma-emitter, their biodistribution could be followed by scintigraphy. We have imaged the biodistribution of a synthetic branched polypeptide, based on a poly-L-lysine backbone (average molecular mass 45 kDa). The polymer was conjugated to diethylene triamine penta-acetic acid and labelled by chelation with indium-111. Mice were injected i.v. with labelled material and imaged with a gamma-camera with a pin-hole collimator. Images showed the majority of tracer remaining in the blood pool, but about 35% appeared in the urinary bladder within 1.5 h. When the 111In-polymer was fractionated by gel filtration chromatography on S-300, the imaging showed that the early eluting material was retained, the intermediate showed some renal clearance, and the late was rapidly excreted. These findings show the value of gamma-scintigraphy for biodistribution studies with such polymeric drug carriers and its potential for clinical pharmacokinetic studies.
DOI: 10.1007/BF00177374
Links toward previous steps (curation, corpus...)
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title>Scintigraphic evaluation of the pharmacokinetics of a soluble polymeric drug carrier</title><author><name>Malcolm V. Pimm</name><affiliation wicri:level="1"><mods:affiliation>Cancer Research Campaign Laboratories, University of Nottingham, NG72RD, Nottingham, UK</mods:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Cancer Research Campaign Laboratories, University of Nottingham, NG72RD, Nottingham</wicri:regionArea><wicri:noRegion>Nottingham</wicri:noRegion></affiliation></author><author><name>Alan C. Perkins</name><affiliation wicri:level="1"><mods:affiliation>Department of Medical Physics, University Hospital, NG72UH, Nottingham, UK</mods:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Medical Physics, University Hospital, NG72UH, Nottingham</wicri:regionArea><wicri:noRegion>Nottingham</wicri:noRegion></affiliation></author><author><name>Ference Hudecz</name><affiliation wicri:level="1"><mods:affiliation>Research Group for Peptide Chemistry, Hungarian Academy of Science, L. Eötvös University, 1120, Budapest, Hungary</mods:affiliation><country xml:lang="fr">Hongrie</country><wicri:regionArea>Research Group for Peptide Chemistry, Hungarian Academy of Science, L. Eötvös University, 1120, Budapest</wicri:regionArea><placeName><settlement type="city">Budapest</settlement><region nuts="2">Hongrie centrale</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="RBID">ISTEX:259_1992_Article_BF00177374.pdf</idno><date when="1992">1992</date><idno type="doi">10.1007/BF00177374</idno><idno type="wicri:Area/Main/Corpus">000824</idno><idno type="wicri:Area/Main/Curation">000824</idno><idno type="wicri:Area/Main/Exploration">000307</idno></publicationStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Biodistribution</term><term>Polymers</term><term>Scintigraphy</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="eng">There is a growing interest in the use of macromolecular carriers for therapeutic agents. If these carriers can be labelled with an appropriate gamma-emitter, their biodistribution could be followed by scintigraphy. We have imaged the biodistribution of a synthetic branched polypeptide, based on a poly-L-lysine backbone (average molecular mass 45 kDa). The polymer was conjugated to diethylene triamine penta-acetic acid and labelled by chelation with indium-111. Mice were injected i.v. with labelled material and imaged with a gamma-camera with a pin-hole collimator. Images showed the majority of tracer remaining in the blood pool, but about 35% appeared in the urinary bladder within 1.5 h. When the 111In-polymer was fractionated by gel filtration chromatography on S-300, the imaging showed that the early eluting material was retained, the intermediate showed some renal clearance, and the late was rapidly excreted. These findings show the value of gamma-scintigraphy for biodistribution studies with such polymeric drug carriers and its potential for clinical pharmacokinetic studies.</div></front></TEI><mods xsi:schemaLocation="http://www.loc.gov/mods/v3 file:///applis/istex/home/loadistex/home/etc/xsd/mods.xsd" version="3.4" istexId="8ed112ae5858521abe1dde135888c4091f479c14"><titleInfo lang="eng"><title>Scintigraphic evaluation of the pharmacokinetics of a soluble polymeric drug carrier</title></titleInfo><name type="personal"><namePart type="given">Malcolm V.</namePart><namePart type="family">Pimm</namePart><role><roleTerm type="text">author</roleTerm></role><affiliation>Cancer Research Campaign Laboratories, University of Nottingham, NG72RD, Nottingham, UK</affiliation></name><name type="personal"><namePart type="given">Alan C.</namePart><namePart type="family">Perkins</namePart><role><roleTerm type="text">author</roleTerm></role><affiliation>Department of Medical Physics, University Hospital, NG72UH, Nottingham, UK</affiliation></name><name type="personal"><namePart type="given">Ference</namePart><namePart type="family">Hudecz</namePart><role><roleTerm type="text">author</roleTerm></role><affiliation>Research Group for Peptide Chemistry, Hungarian Academy of Science, L. Eötvös University, 1120, Budapest, Hungary</affiliation></name><typeOfResource>text</typeOfResource><genre>Short Communications</genre><genre>Brief Communication</genre><originInfo><publisher>Springer-Verlag, Berlin/Heidelberg</publisher><dateCreated encoding="w3cdtf">1992-02-22</dateCreated><dateValid encoding="w3cdtf">2004-07-05</dateValid><copyrightDate encoding="w3cdtf">1992</copyrightDate></originInfo><language><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType></physicalDescription><abstract lang="eng">There is a growing interest in the use of macromolecular carriers for therapeutic agents. If these carriers can be labelled with an appropriate gamma-emitter, their biodistribution could be followed by scintigraphy. We have imaged the biodistribution of a synthetic branched polypeptide, based on a poly-L-lysine backbone (average molecular mass 45 kDa). The polymer was conjugated to diethylene triamine penta-acetic acid and labelled by chelation with indium-111. Mice were injected i.v. with labelled material and imaged with a gamma-camera with a pin-hole collimator. Images showed the majority of tracer remaining in the blood pool, but about 35% appeared in the urinary bladder within 1.5 h. When the 111In-polymer was fractionated by gel filtration chromatography on S-300, the imaging showed that the early eluting material was retained, the intermediate showed some renal clearance, and the late was rapidly excreted. These findings show the value of gamma-scintigraphy for biodistribution studies with such polymeric drug carriers and its potential for clinical pharmacokinetic studies.</abstract><subject lang="eng"><genre>Key words</genre><topic>Scintigraphy</topic><topic>Polymers</topic><topic>Biodistribution</topic></subject><relatedItem type="series"><titleInfo type="abbreviated"><title>Eur J Nucl Med</title></titleInfo><titleInfo><title>European Journal of Nuclear Medicine</title><partNumber>Year: 1992</partNumber><partNumber>Volume: 19</partNumber><partNumber>Number: 6</partNumber></titleInfo><genre>Archive Journal</genre><originInfo><dateIssued encoding="w3cdtf">1992-06-01</dateIssued><copyrightDate encoding="w3cdtf">1992</copyrightDate></originInfo><subject usage="primary"><topic>Medicine & Public Health</topic><topic>Imaging / Radiology</topic><topic>Nuclear Medicine</topic></subject><identifier type="issn">0340-6997</identifier><identifier type="issn">Electronic: 1619-7089</identifier><identifier type="matrixNumber">259</identifier><identifier type="local">IssueArticleCount: 15</identifier><recordInfo><recordOrigin>Springer-Verlag, 1992</recordOrigin></recordInfo></relatedItem><identifier type="doi">10.1007/BF00177374</identifier><identifier type="matrixNumber">Art12</identifier><identifier type="local">BF00177374</identifier><accessCondition type="use and reproduction">MetadataGrant: OpenAccess</accessCondition><accessCondition type="use and reproduction">AbstractGrant: OpenAccess</accessCondition><accessCondition type="restriction on access">BodyPDFGrant: Restricted</accessCondition><accessCondition type="restriction on access">BodyHTMLGrant: Restricted</accessCondition><accessCondition type="restriction on access">BibliographyGrant: Restricted</accessCondition><accessCondition type="restriction on access">ESMGrant: Restricted</accessCondition><part><extent unit="pages"><start>449</start><end>452</end></extent></part><recordInfo><recordOrigin>Springer-Verlag, 1992</recordOrigin><recordIdentifier>259_1992_Article_BF00177374.pdf</recordIdentifier></recordInfo></mods></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=IndiumV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000307 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000307 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= *** parameter Area/wikiCode missing ***
|area= IndiumV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= ISTEX:259_1992_Article_BF00177374.pdf
|texte= Scintigraphic evaluation of the pharmacokinetics of a soluble polymeric drug carrier
}}
| This area was generated with Dilib version V0.5.81. |  |